Publications
Text queries can be conducted by Author, Title, or Keyword.
Reduced white matter integrity in Attention-Deficit/Hyperactivity Disorder
Source: NeuroReport 2008 Nov;19(17):1705-1708.
Author: Hamilton LS, Levitt JG, O’Neill J, Alger JR, Luders E, Phillips OR, Caplan R, Toga AW, McCracken J, Narr KL
PubMed ID: 18841089
Abstract:
We used diffusion tensor imaging (DTI) to investigate fractional anisotropy (FA), a measure of fiber tract integrity, in attention-deficit hyperactivity disorder (ADHD). Using a tract-based atlasing approach on sixdirection DTI data, we examined FA within the cingulum, corpus callosum, corticospinal tract, fornix, optic radiations, superior longitudinal fasciculus, uncinate fasciculus, and the superior and inferior occipitofrontal fasciculi in an all-male sample of 17 children and adolescents with ADHD and 16 agematched controls. ADHD subjects had significantly lower FA in the corticospinal tract (p=0.02) and the superior longitudinal fasciculus (p=0.017) compared to controls. Results support that disruptions in motor and attentional networks may contribute toward ADHD pathophysiology. Future research may clarify how ADHD subtype and psychiatric comorbidities affect diffusion measures.
Source: NeuroReport 2008 Nov;19(17):1705-1708.
Author: Hamilton LS, Levitt JG, O’Neill J, Alger JR, Luders E, Phillips OR, Caplan R, Toga AW, McCracken J, Narr KL
PubMed ID: 18841089
Abstract:
We used diffusion tensor imaging (DTI) to investigate fractional anisotropy (FA), a measure of fiber tract integrity, in attention-deficit hyperactivity disorder (ADHD). Using a tract-based atlasing approach on sixdirection DTI data, we examined FA within the cingulum, corpus callosum, corticospinal tract, fornix, optic radiations, superior longitudinal fasciculus, uncinate fasciculus, and the superior and inferior occipitofrontal fasciculi in an all-male sample of 17 children and adolescents with ADHD and 16 agematched controls. ADHD subjects had significantly lower FA in the corticospinal tract (p=0.02) and the superior longitudinal fasciculus (p=0.017) compared to controls. Results support that disruptions in motor and attentional networks may contribute toward ADHD pathophysiology. Future research may clarify how ADHD subtype and psychiatric comorbidities affect diffusion measures.