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Mapping cerebellar degeneration in HIV/AIDS
Source: NeuroReport 2008 Nov;19(17):1655-1659.
Author: Klunder AD, Chiang MC, Dutton RA, Lee SE, Toga AW, Lopez OL, Aizenstein HJ, Becker JT, Thompson PM
PubMed ID: 18806691
Abstract:
Progressive brain atrophy in HIV/AIDS is associatedwith impaired psychomotor performance, perhaps partly re£ecting cerebellar degeneration; yet little is known about how HIV/AIDS a¡ects the cerebellum.We visualized the three-dimensional pro¢le of atrophy in 19 HIV-positive patients (age: 42.978.3years) versus 15 healthy controls (age: 38.5712.0 years).We localized consistent patterns of subregional atrophy with animage analysismethod that automatically deforms each patient’s scan, in three dimensions, to match a reference image. Atrophy was greatest in the posterior cerebellar vermis (14.9% de¢cit) and correlated with depression severity (P¼0.009, corrected), but not with dementia, alcohol/substance abuse,CD4+T-cell counts, or viral load. Profound cerebellar de¢- cits in HIV/AIDS (P¼0.007, corrected) were associated with depression, suggesting a surrogate diseasemarker for antiretroviral trials. NeuroReport 00:000^000c 2008Wolters Kluwer Health | LippincottWilliams &Wilkins.
Source: NeuroReport 2008 Nov;19(17):1655-1659.
Author: Klunder AD, Chiang MC, Dutton RA, Lee SE, Toga AW, Lopez OL, Aizenstein HJ, Becker JT, Thompson PM
PubMed ID: 18806691
Abstract:
Progressive brain atrophy in HIV/AIDS is associatedwith impaired psychomotor performance, perhaps partly re£ecting cerebellar degeneration; yet little is known about how HIV/AIDS a¡ects the cerebellum.We visualized the three-dimensional pro¢le of atrophy in 19 HIV-positive patients (age: 42.978.3years) versus 15 healthy controls (age: 38.5712.0 years).We localized consistent patterns of subregional atrophy with animage analysismethod that automatically deforms each patient’s scan, in three dimensions, to match a reference image. Atrophy was greatest in the posterior cerebellar vermis (14.9% de¢cit) and correlated with depression severity (P¼0.009, corrected), but not with dementia, alcohol/substance abuse,CD4+T-cell counts, or viral load. Profound cerebellar de¢- cits in HIV/AIDS (P¼0.007, corrected) were associated with depression, suggesting a surrogate diseasemarker for antiretroviral trials. NeuroReport 00:000^000c 2008Wolters Kluwer Health | LippincottWilliams &Wilkins.