Publications
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Mapping cerebellar vermal morphology and cognitive correlates in prenatal alcohol exposure
Source: Development Neuroscience 2005 Aug;16(12):1285-1290.
Author: O'Hare ED, Kan E, Yoshii J, Mattson SN, Riley EP, Thompson PM, Toga AW, Sowell ER.
PubMed ID: 16056126
Abstract:
Prenatal exposure to alcohol can result in neuroanatomical and neurocognitive de¢cits. High-resolution magnetic resonance imaging, surface-basedimage analyticmethods, andneuropsychological measures were used to characterize the cerebellar vermis and to evaluate potential cognitive correlates of vermalmorphology in 21 children and adolescents with prenatal alcohol exposure and 21 normally developing individuals. Alcohol-exposed individuals showed statistically signi¢cant reductions in the midline sagittal areas of the anterior vermis and posterior-inferior vermis, and signi¢cant displacement of the anterior and posterior-inferior vermal regions. Anterior vermal dysmorphology was negatively correlated with verbal learning and memory performance within the alcohol-exposed group. These observations expand on previous reports of cerebellar abnormalities in prenatal alcohol exposure, in that they localize the speci¢c pattern of cerebellar vermal dysmorphology.
Source: Development Neuroscience 2005 Aug;16(12):1285-1290.
Author: O'Hare ED, Kan E, Yoshii J, Mattson SN, Riley EP, Thompson PM, Toga AW, Sowell ER.
PubMed ID: 16056126
Abstract:
Prenatal exposure to alcohol can result in neuroanatomical and neurocognitive de¢cits. High-resolution magnetic resonance imaging, surface-basedimage analyticmethods, andneuropsychological measures were used to characterize the cerebellar vermis and to evaluate potential cognitive correlates of vermalmorphology in 21 children and adolescents with prenatal alcohol exposure and 21 normally developing individuals. Alcohol-exposed individuals showed statistically signi¢cant reductions in the midline sagittal areas of the anterior vermis and posterior-inferior vermis, and signi¢cant displacement of the anterior and posterior-inferior vermal regions. Anterior vermal dysmorphology was negatively correlated with verbal learning and memory performance within the alcohol-exposed group. These observations expand on previous reports of cerebellar abnormalities in prenatal alcohol exposure, in that they localize the speci¢c pattern of cerebellar vermal dysmorphology.