Abstract:
Image registration is a prerequisite to numerous imaging applications in the neurosciences.
Registration is required for three dimensional reconstruction, multimodality image mappings,
atlas construction and arithmetic operations such as image averaging, subtraction and correlation.
Physical sectioning procedures, unlike various tomographic imaging techniques, also require
additional superpositioning schemes to register serial sections. Since the mid-1980's investigators
have used several approaches, with varying degrees of manual interaction, to perform image
registration. These approaches use either information obtained about the shape and topology
of objects in the image, or the presumed consistency in the intensity information from one slice to its
immediate neighbor, or from one brain or image set to another.