Publications
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Characterization of optical intrinsic signals and blood volume
during cortical spreading depression
Source: Neuroreport 2000 Jul;11(10):2121-2125.
Author: O'Farrell AM, Rex DE, Muthialu A, Pouratian N, Wong GK, Cannestra AF, Chen JW, Toga AW.
PubMed ID: 10923656
Abstract:
Cortical spreading depression (CSD) was imaged in vivo in a rodent model with optical intrinsic signals (OIS). This is the first study to identify a triphasic OIS response and to characterize the rate and timing of the response. The initial OIS phase had a highly uniform wavefront, which spread at a rate characteristic of CSD, 3.5 mm/min. Later phases were more diffuse and inhomogeneous. Blood volume changes, measured with intravascular fluorescent dye, correlated in time and location with the later phases of OIS response. This suggests that the inhomogeneity of the late OIS response may be due to complex residual hemodynamic contributions, as opposed to underlying cortical circuitry.
Source: Neuroreport 2000 Jul;11(10):2121-2125.
Author: O'Farrell AM, Rex DE, Muthialu A, Pouratian N, Wong GK, Cannestra AF, Chen JW, Toga AW.
PubMed ID: 10923656
Abstract:
Cortical spreading depression (CSD) was imaged in vivo in a rodent model with optical intrinsic signals (OIS). This is the first study to identify a triphasic OIS response and to characterize the rate and timing of the response. The initial OIS phase had a highly uniform wavefront, which spread at a rate characteristic of CSD, 3.5 mm/min. Later phases were more diffuse and inhomogeneous. Blood volume changes, measured with intravascular fluorescent dye, correlated in time and location with the later phases of OIS response. This suggests that the inhomogeneity of the late OIS response may be due to complex residual hemodynamic contributions, as opposed to underlying cortical circuitry.