Effects of the lateral septum and latent inhibition on successive
discrimination learning
Source: J Neurosci Res
1979;4(3):215-224.
Author: Toga AW & Burton HA PubMed ID: 509223
Abstract:
Damage to the lateral nucleus of the septum in the rat resulted in
atypical learning to a previously meaningless stimulus. Nonreinforced
preexposure to a stimulus normally makes more difficult subsequent use of that stimulus for learning. The effect of this preexposure on
learning is termed latent inhibition and was demonstrated in sham
operated animals. Rats in which the lateral septum was damaged
demonstrated a paradoxically smaller learning deficit in the presence of
a conditioned stimulus that was previously presented without
reinforcement, when compared to the performance of both septal lesioned rats no receiving nonreinforced preexposure and sham operates receiving preexposure. The interaction of nonreinforced preexposure and lateral septal lesions can be explained using a proposed sensitization hypothesis.